Sentence examples for manner in breast from inspiring English sources
Although antiestrogens are thought to largely act by antagonizing the actions of estrogens, we have found among several new ER-regulated genes, quinone reductase (QR), a detoxifying phase II antioxidant enzyme, that has its activity up-regulated by antiestrogens in an ER-dependent manner in breast cancer cells.
For example, in addition to modulating the activity of deacetylase SIRT1 in an AMPK-dependent manner in breast cancer cells (Ferrer et al., 2017), OGT-mediated O-GlcNAcylation can also affect cancer cell growth and invasion through regulating the oncogenic transcription factor FOXM1 (Caldwell et al., 2010), suggesting the interplay of O-GlcNAcylation and SIRT1 in cancer cells.
Furthermore, MKK3 and the p38-activated kinase MAPKAPK2 (MK2) were shown to be involved in ARE-mediated mRNA stabilization in a Rac dependent manner in breast cancer cells [33].
Hsp70 has been shown to be exported via exosomes in immune cells so it is possible that Hsp70 and the other co-chaperones are exported in a similar manner in breast cancer cells.
The evidence that activated Stat3 participates in a causal manner in breast tumorigenesis is based on studies from cell lines expressing high levels of pStat3.
For example, it has been demonstrated that metformin down-regulates c-MYC in an AMPK-dependent manner in breast cancer cell lines [ 94].
We asked if USP33 in lung cancer cells acted in a similar manner as in breast cancer cells.
Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces the hTERT gene repression in a BMPRII receptor- and Smad3-dependent manner in human breast cancer cells.
To our surprise, we discovered that SFN can considerably inhibit DNMT1 and 3a expression in a dose-dependent manner in human breast cancer cells and the inhibition was less in normal MCF10A cells.
Having determined that GPNMB/OA is constitutively shed in an ADAM10-dependent manner in our breast cancer model systems, we next investigated whether this shed GPNMB/OA ECD possessed angiogenic properties.
Interestingly, TGF-β1 induced Smad3 and Smad4 interaction was increased in the presence of H2O2 in cells expressing WT-BRCA1, while the TGF-β1 induced interaction between Smad3 and Smad4 was decreased upon H2O2 treatment in a dose-dependent manner in HCC1937 breast cancer cells, deficient for endogenous BRCA1.
