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pHCV-IRES, a bicistronic reporter plasmid that expresses renilla luciferase in a 5′ cap-dependent manner in addition to firefly luciferase directed by HCV IRES, was used to determine the effect of RBM24 on HCV translation in the context of RBM24 knockdown or overexpression.
These are required for constitutive pre-mRNA splicing but also regulate alternative splice site selection in a concentration-dependent manner in addition to other documented roles in transcription, nucleo-cytoplasmic transport and translation (reviewed in [36]).
As shown in Fig 1D, if the same value of threshold (−10.27) is used, but in a fixed, location independent manner, in addition to these 55 functional (i.e. proximal) BSs one identifies about 250 stray ones that are not at the functional location.
We observed chromatin relaxation in a dose-dependent manner in addition to increases in H3K9 and H4K12 acetylation at the 3-hr time point in HEK293T cells.
Based on a literature search in the PubMed database, we identified 33 genes that are regulated in a β-catenin dependent manner in addition to the 33 β-catenin target genes published by Roel Nusse.
Resveratrol and DHEA exerted inhibitory effects on TXNIP in a tissue specific manner, in addition, they were found to act on separate branches of the glycolytic pathway mediated respectively by AMPK and Glucose 6 phosphate dehydrogenase respectively.
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The Johnson-Kennedy antagonism also teaches that a president should mind his staff's manners in addition to his own.
By 1742, critic and essayist Samuel Johnson was recommending that travellers engage in "a moral and ethical study of men and manners" in addition to a scientific study of topography and geography.
The following is a list of things you can say to help deal with the issue in a lighthearted manner: 1)."In addition to diapers, maybe I can start wearing a life preserver or life jacket to bed".
In contrast, the number of PI-incorporating cells diminished significantly and in a dose-dependent manner in response to addition of anti-CD45.2 (Figs. 11 12).
As shown in Figure 2, cell proliferation was affected by irradiation alone in a dose-dependent manner; in contrast, the addition of 5 mmol/L doranidazole significantly reduced the cell survival rate under hypoxic conditions.
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