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Both pathways appear to be regulated in a very tight manner during embryogenesis.
Ephrin B1 acts both as a ligand and as a receptor in a tissue-specific manner during embryogenesis and is critically important in many biological processes including axon guidance, neural crest migration [66], [67].
This tight regulation depends on epigenetic marks, mainly methylation marks established in a parental specific manner during embryogenesis.
As germ cell specification takes place in a region different from the site of gonad formation, PGCs have to migrate in a directional manner during embryogenesis.
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Immunohistochemical analysis shows that Esrrg is widely expressed in a site-specific manner during mouse embryogenesis.
These two cell populations interact in a complex, reciprocal manner as the mammary primordium forms during embryogenesis.
It has been suggested that increased expression of pha-4 during DR or TOR inhibition facilitates its binding to DR-specific genes, in an analogous manner to its expression and binding specificity during embryogenesis (Panowski et al., 2007).
The fact that these typical neural stem cell markers are expressed in confined region of the neuroepithelium during embryogenesis in lampreys, and in a highly comparable manner when compared to studied gnathostome species, suggest that the molecular mechanisms controlling neural "stemcellness" and the renewal of neural progenitors are shared –at least in part- by all the craniates.
It becomes increasingly evident that autophagic activity is controlled similarly in a developmentally regulated manner and that it plays an essential role during development., Especially during embryogenesis, a rapid change from quiescence to enhanced metabolism facilitates proliferation, differentiation, migration and death.
In man, more than 65 genes code for distinct IF proteins that are expressed during embryogenesis in various routes of differentiation in a tightly controlled manner.
Our findings provide insights into the functional versatility of transcription factors during embryogenesis, during which they can be recursively utilized in a variable manner within discrete network structures.
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