Crucially, neutrophil coincubation with MCMV-infected fibroblasts dramatically reduced the production of replicative virions in a cell-number-dependent manner, demonstrating that neutrophils directly inhibit MCMV replication.
In addition, BV6 triggered DNA fragmentation, a biochemical hallmark of apoptosis, in a concentration-dependent manner, demonstrating that BV6 induces apoptotic cell death.
Besides, the inhibition of uptake of folate-decorated CNPs by free FA in a dose-dependent manner demonstrates that the particle uptake is mediated by the FA receptor (Fig. 7c).
However, in the HC group, the mitochondrial ATP levels in PMNs decreased with fMLP stimulation in a dose-dependent manner, demonstrating that the mitochondrial ATP was consumed in this process in healthy PMNs.
Moreover, the assessment of MMP, the determination of intracellular free Ca2+ concentration, the production of ROS, and the effects on the activity of caspase-3 in a dose-dependent manner demonstrated that compound 21 induced cell apoptosis in HepG2 cells through the Ca2+/ROS-mediated mitochondria/caspase-dependent apoptosis pathway largely.
Here, we show that LhrA acts to down regulate the expression of lmo0302 and chiA at the post-transcriptional level in an Hfq-dependent manner, demonstrating that LhrA is a multiple target regulator in L. monocytogenes.
AII increased luciferase activity in a concentration dependent manner, demonstrating that AII promoted NHE3 gene transcription.
Pmp21 coated latex beads are endocytosed in an EGFR-dependent manner demonstrating that Pmp21 is sufficient to trigger invasion [ 12].
LP99 inhibited IL-6 secretion from THP-1 cells in a dose-dependent manner, demonstrating that BRD7/9 BRDs are potential targets for anti-inflammatory treatment.
As shown in Figure 4, there was a significant G0/G1 phase arrest in a time-dependent manner demonstrating that AMEAE arrested cell cycle progression at the G0/G1 phase.
