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In HEK-293 cells and cultured hippocampal neurons expressing this magnetoreceptor, application of an external magnetic field resulted in membrane depolarization and calcium influx in a reproducible and reversible manner, as indicated by the ultrasensitive fluorescent calcium indicator GCaMP6s.

MCRT was found to induce analgesic activity in a dose- and time-dependent manner, as indicated by a tail flick latency test in mice to which it had been intracerebroventricularly administered (5 60 min, 0.025 2.5 nmol/kg (0.5 50 pmol per mouse), ED50 = 1.49 nmol/kg).

It is important to recall here that the specimens used in the previous study were prepared in the same standardized manner as indicated in the previous paragraph.

We found that the nanomachines increased the rate of thrombolysis of urokinase in a concentration-dependent manner, as indicated by a greater number of blood block fragments and fluorescence intensity.

After application of 161Tb-folate, kidney function was reduced in a dose- and time-dependent manner, as indicated by the decreased renal uptake of 99mTc-DMSA and the increased levels of blood urea nitrogen and creatinine.

On the other hand, visual well-being and comfort (Fig. 4, middle panel) differed in a wavelength-dependent manner, as indicated by a significant two-way interaction of the factors "light condition" and "session" (F6,17 = 1.4, p = 0.04).

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ΔΨm was reduced in a time-dependent manner after ETO exposure as indicated by the decrease of the red/green ratio.

Preincubation of the arteries with methylglyoxal significantly reduced acetylcholine-induced vasorelaxation in the presence of 10 µmol/l indometacin in a concentration-dependent manner (Fig.  3a), as indicated by a significantly decreased efficacy (Emax in presence of 0, 0.33 0.33 and 1.0 mmol/l methylglyoxal 62 ± 3, 57 ± 1, 48 ± 3 and 39 ± 3%, respectively; p < 0.001).

Further analyses of the Vpr effect on neuroblastoma cells indicated that Vpr induces cell death in a dose-dependent manner (Figure 3A B) via apoptosis as indicated by caspase-3 cleavage (Figure 3C).

Indeed, Mb administration was able to inhibit cell proliferation in a dose-dependent manner and to induce apoptosis as indicated by Tunel assay, showing a marked increase in the number of apoptotic nuclei upon 6 days of Mb treatment.

Yet sometimes the disobedience may be of such a character and in such a manner as to indicate a contempt of the court rather than a disregard of the rights of the adverse party.

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