Sentence examples for manner as demonstrated from inspiring English sources

Compounds of this type are also accessible in a complementary manner, as demonstrated by the reactions of [1′- diphenylphosphino)ferrocenyl]methylamine with carboxylic acids (or their derivatives) and isocyanates.

Transfection of rhabdomyosarcoma (RD) cells with the 29-mer shRNAs significantly inhibited EV71 replication in a dose-dependent manner as demonstrated by reduction of viral RNA, VP1 protein and plaque forming units.

Accordingly, p300 is recruited onto the chromatin of NF-Y target genes in a NF-Y-dependent manner, as demonstrated by Re-ChIP.

These data clearly demonstrated that the immune response to PrP after DC vaccination can inhibit PrPSc replication in a very efficient manner as demonstrated by the nearly absence of early accumulation of PrPSc in the spleen of DCTg650AdTA-treated mice.

As expected from the previously published analyses of these populations [6]-[8], the MDM2 SNP309 locus affects the age of tumor diagnosis in a significant manner as demonstrated by a significant level of mutual information (0.10 bits, p = 0.007, Permutation Test).

Interestingly, this analysis revealed that the MDM2 SNP309 locus and gender taken together interact to affect the age of tumor diagnosis in a non-additive, synergistic manner, as demonstrated by the measured 0.06 bits of significant synergistic information (p = 0.05, Permutation Test).

Right/Left K - Look as demonstrated.

Although B cell activation can occur independently of T cell help in lupus, a substantial fraction of B cells is activated in a T cell dependent manner [ 8- 10], as demonstrated by isotype switching and affinity maturation of B cells [ 11, 12] and enhanced CD154-CD40 interactions [ 13].

These "unhelpful" responses are therefore potentially being interpreted in a similar negative manner, possibly as demonstrating a lack of empathy or invalidation of the patient's suffering by the significant other.

Gene delivery is an important tool that may help to address the limitations of cytokine therapy mentioned above and permit local cytokine delivery in a safe and effective manner, as has already been demonstrated in many studies conducted in animal models of arthritis.

The upregulation of the above genes takes place in a direct manner, as we demonstrated, conserved LEF-binding sites in MMP-9, 13, 14, ADAMTS-5, and COL10A1 promoters, responsible for their promoter activity and is associated directly with the β-catenin/LEF-1 complex.