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In rats it has been shown that chronic treatment with different migraine prophylactic drugs suppresses cortical spreading depression in a duration-dependent manner and increases the electrical stimulation threshold [38].
Our data indicate that p27Kip1 deficiency in PEC promotes cell proliferation in an age-dependent manner and increases cellular response to hormone stimulation.
SCR7 reduces cell proliferation in a DNA ligase IV-dependent mander and increases the tumor-inhibitory effects of agents that cause DSBs.
AIB1 is a member of the SRC family that interacts with ERα in a ligand-dependent manner and increases estrogen-dependent transcription [ 2].
AIB1 (amplified in breast 1) is a member of the steroid receptor coactivator (SRC) family that interacts with estrogen receptor (ER)α in a ligand-dependent manner, and increases estrogen-dependent transcription [ 2].
Likewise, it has been shown that the PWWP domain-containing protein EXPAND1 accumulates in IRIF in a H2AX, MDC1, RNF8 and 53BP1-dependent manner and increases chromatin accessibility after DNA damage [ 28].
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Kip3 slowed microtubule growth in a length-dependent manner and increased the rate of aging.
Furthermore, analogue 3′a could decrease Bax protein levels in a concentration-dependent manner and increase Bcl-2 protein expression, which was accompanied by increasing chances of cell survival.
Articaine and lidocaine inhibited the stimulation-evoked release in a concentration-dependent manner and increased the resting release by two to six times.
Rat mesenteric arteries were incubated with CsA in an organ culture system, and results showed that CsA enhanced ETB receptor mRNA in the time- and dose-dependent manner, and increased protein expression levels of ETB receptor after treatment with CsA 10−5 M for 6 h.
Specifically, PTH elevated levels of ATF4 mRNA and protein in a dose and time-dependent manner and increased binding of ATF4 to OSE1 DNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com