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As for the MoveOn parties, they took place throughout Monday evening in almost every conceivable manner and function across the United States, including at exclusive celebrity events, clubs, bars and homes.
Cytokines are peptides that are produced by virtually every nucleated cell type in the body, possess overlapping biological activities, exert different effects at different concentrations, can either synergize or antagonize the effects of other cytokines, are regulated in a complex manner, and function via cytokine cascades.
Many alternative isoforms are expressed in a spatio-temporal manner, and function in diverse processes, including in the neural system.
They are produced by ovarian granulosa cells and oocytes in a developmental, stage-related manner and function as intra-ovarian regulators of folliculogenesis.
Many members of TGF-β superfamily are expressed by ovarian somatic cells and oocytes in a developmental stage-related manner and function as intraovarian regulators of folliculogenesis.
Many intergenic CSSs may act in a similar manner and function as a switch due to the alternative binding of transcription factors directly affecting the temporal expression of target genes.
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In low-Fe condition, Aft1p can shuttle between the cytosol and the nucleus in an iron-responsive manner, and functions as a transcriptional activator of iron regulon genes, which subsequently activate high-affinity iron uptake systems (Berthelet et al., 2010; Lill et al., 2012).
An element (-40 to -25) that overlaps one of the E2F binding sites can be bound and activated by 53BP1 in a sequence-specific manner and functions as a positive regulatory element [ 21].
Mechanistic investigations showed that HIF-1 α translation was upregulated in p27-deficient cells in an S6 phosphorylation-dependent manner and functioned as a driving force in arsenite-induced cell transformation.
In other recent studies, it has been shown that leucyl-tRNA synthetase (LARS) can also act as an amino acid sensor., The enzyme directly binds to RRAG GTPase in a leucine-dependent manner and functions as a GTPase-activating protein for RRAG GTPase to activate MTORC1.
Interest in the tRNA mechanism revived with the finding that leucyl-tRNA synthetase directly binds to Rag GTPase in a leucine-dependent manner and functions as a GTPase-activating protein (GAP) for Rag GTPase to activate MTORC1 (Han et al. 2012).
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