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As we have little manipulative capability to guide the cellular DNA repair process to achieve a given outcome, current best practice is to screen through the pool of targeted cells or organisms for a specific modification at the targeted locus.
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These similarities can be related to the enhanced manipulative capabilities displayed by these monkeys [27] [29].
It seem likely that the acquisition of habitual bipedalism which largely freed the upper extremities from locomotor demands [14] would have facilitated the refining of the manipulative capabilities displayed by all primates [e.g. 1] [2], [5], [12], [28], [33].
Extant great apes are highly committed to arboreal locomotion (including vertical climbing and suspensory behaviors), their manipulative capabilities being limited by their relative short thumbs [1] [2], [5], and especially by their absolutely long hands [12].
According to this, the enhanced manipulative capabilities displayed by baboons could be merely a by-product of an adaptation of the hand to digitigrady, resulting in a long thumb relative to the rest of the hand that would be suitable for pad-to-pad precision grasping (see Fig. 8a b in [28]).
With the advent of terrestrial bipedalism, these hand proportions may have been co-opted by early hominins for enhanced manipulative capabilities that, in turn, would have been later co-opted for stone tool-making in the genus Homo, more encephalized than the previous australopiths.
SMT spinal manipulative therapy (spinal manipulation).
Totally manipulative.
It's totally manipulative.
The manipulative Yankees.
Is that manipulative?
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