Sentence examples for manipulation of synaptic from inspiring English sources

These results demonstrate a clear dissociation between SWM and SRM on the radial maze following the manipulation of synaptic plasticity exclusively within the DG of the hippocampal formation.

The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling.

The task is sensitive to lesions of the hippocampus [1 3] and to subtle manipulations of hippocampal synaptic plasticity [4].

Because some of these proteins are enriched at the neuromuscular synapse, the manipulation of factors governing synaptic transcription is a promising new approach to the treatment of muscular dystrophy.

Pharmacotherapies can increase neuroplasticity through molecular manipulation of numerous cellular and synaptic pathways, such as HDAC inhibitors, mTOR inhibitors and trkB agonists (Vecsey et al., 2007; Potter et al., 2010).

Although manipulation of these enzymatic activities impacted synaptic vesicle endocytosis, it is seems likely that these manipulations do not solely alter dynamin activity given that they target numerous substrates.

In Figure 6, we show how mean firing rate clamping can be achieved even during gross manipulation of network connectivity using different synaptic blockers, but unsurprisingly, the short time-scale features of population firing activity are greatly affected by these perturbations even though mean firing levels are maintained.

However, very little is known about the consequences of combining models of synaptic dysfunction with controlled environmental manipulations.

Genetic and pharmacological manipulations revealed that reduced PKG (or PP2A) activity caused increased thermotolerance of synaptic transmission at the larval neuromuscular junction.

However, the time course of expression of nNOS is co-extensive with the period of synaptic withdrawal from the cell body (Sunico et al., 2005) and pharmacological manipulation of nNOS shows that in the absence of NO presynaptic withdrawal is arrested.

Our results revealed robust effects of in vivo manipulation of neuronal activity in the hippocampus on synaptic and intrinsic properties.