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This algorithm allows manipulation of several parameters controlling the resultant cluster size and cohesiveness.
Confirmation has been obtained from analyses of Arabidopsis thaliana AsA deficient mutants [ 11, 12] and from identification and manipulation of several of the genes involved [ 13- 15].
The definitive identification of the gene(s) involved will require fine mapping of the 25-Mbp region determined in our coarse mapping experiments, and additional specific genetic manipulation of several putative targets.
The continuous expansion of the genetic toolbox available for S. cerevisiae allowing manipulation of several genetic elements in a single round of transformation for strain development has placed yeast as the preferred host for bio-based production.
It is possible that manipulation of several variables at the same time, and possibly other characteristics of our study, created a situation with more cognitive load, which was harder for the developmental dyscalculia participants to cope with.
Intriguingly, experimental manipulation of several cell cycle proteins as well as activation of a variety of signaling pathways including Notch, neuregulin1/ErbB4, Fgf-1, Pi3K, and Akt signaling can stimulate cell cycle re-entry in differentiated mature mammalian CMs [ 40– 40].
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While manipulations of several different brain areas can produce initiation or cessation of food consumption, it remains unknown whether neurons exist whose endogenous in vivo spiking activity parallels the slowly increasing and rapidly terminating drive state associated with food seeking.
The questionnaire provides information about the site of pain and the relative effects of a given manipulation on several dimensions of pain.
Similarly to our observations, C57 mice are often reported to be resistant to the influence of early life manipulations on several aspects of adult behavior, including cognitive abilities, depression-related and schizophrenia-related behaviors [34], [36] [38].
Innovative strategies to improve peripheral nerve regeneration are expected to arise from the manipulation of the several trophic factor loops playing a role in this process.
The UK BEAM pragmatic trial estimated the effect of adding exercise classes, a spinal manipulation package (a combination of several manual techniques), or spinal manipulation followed by exercise, to "best care" in general practice for patients consulting with back pain [ 15].
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