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Tools for in vivo manipulation of protein abundance or activity are highly beneficial for life science research.
Loynachan is now doing research with Polina Anikeeva, the AMAX Career Development Assistant Professor in Materials Engineering at MIT, developing methods for remote manipulation of protein aggregation using targeted magnetic nanoparticles for potential disease therapies.
Understanding the nanoparticle protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution.
The manipulation of protein stability with small molecules has great potential as a technique for aiding the development of clinical therapies, including treatments for cancer.
Experimental manipulation of protein abundance in living cells or organisms is an essential strategy for investigation of biological regulatory mechanisms.
These two variants can be expected to be highly useful for in vivo manipulation of protein abundance by light.
Similar(41)
Macromolecular crowding effects may be a tool for the manipulation of protein-folding and function in living cells.
Pan, Y., Du, X. W., Zhao, F. & Xu, B. Magnetic nanoparticles for the manipulation of proteins and cells.
Novel strategies have been developed to use intein-catalyzed reactions for the production and manipulation of proteins and peptides.
Protein-templated reactions have been used for fragment-based drug discovery as well as for covalent labeling, detection and manipulation of proteins.
With this challenge in mind, we review the contents of the modern molecular engineering toolbox that allow the manipulation of proteins in a site-specific and chemically well-defined fashion.
More suggestions(15)
manipulation of content
manipulation of grain
manipulation of disease
manipulation of albumin
practice of protein
interference of protein
exploitation of protein
manipulation of gene
manipulation of quality
manipulation of body
manipulation of error-weighting
manipulation of light
manipulation of identity
manipulation of nature
manipulation of test
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