Sentence examples for manipulation of primary from inspiring English sources

Genetic manipulation of primary macrophages and CD4+ T cells by shRNA methodologies poses considerable technical challenges.

In summary, our study investigated the possibility of minimizing the ex vivo manipulation of primary CD34+ cells for use in clinical applications with the primary aim of maintaining safety and efficacy.

The extended window of proliferation afforded by 3D culture, prior to plating cells in monolayer, provides an operational advantage for genetic manipulation of primary cultures of non-immortalised MECs, because it permits sufficient time for gene deletion, e.g. using Cre-mediated recombination or mRNA depletion with shRNA, to enable mechanistic studies on cell cycle regulation.

Moreover, gene manipulation of primary cells is known to be challenging due to unsatisfactory expression of the exogenous gene.

Ex vivo studies involve the manipulation of primary clinical samples of Plasmodium spp. in an artificial environment for no longer than 48 h.

Still, unraveling the proximate mechanisms underlying manipulation of primary offspring sex ratio is an ongoing quest (Krackow 1995; Pike and Petrie 2003; Alonso-Alvarez 2006).

Health economic evaluations in general are vulnerable to manipulation due to the use of primary data and the arbitrary definition of outcomes.

The NUT's motion stated that the union "condemned the manipulation of the primary curriculum and teaching methods through the imposition of unnecessary tests, in particular Year 1 phonics screening and the Year 6 spelling, punctuation and grammar test".

As a consequence, manipulation of the primary tumour may have beneficial, detrimental, or no effect on the other elements.

Surgical manipulation of the primary tumor is associated with the shedding of tumor cells into the circulation in animal studies and an increase in metastatic proliferation [ 38, 39].

This may indicate that surgical manipulation of the primary tumours in these individuals has resulted in dissemination of tumour cells into the circulation but the clinical relevance of cells disseminated by surgery is a subject of debate.