The understanding and potential manipulation of the mechanisms of thermotolerance and response to stresses in cereals, either by transgenic approaches or by molecular breeding, will rely on further achievements in genomics, proteomics and metabolic profiling.
Moreover, the manipulation of fragile mechanisms in a therapeutic context, which has been suggested by Kitano [29] to be more likely to elicit an efficacious response from a network or system, should also be prevalent in the treatment literature.
Manipulation of these mechanisms at the genetic level offers several advantages over exogenous application of substances.
Hence, a reasonable approach to protect the heart in DM patients is manipulation of protective mechanisms at the level of GSK-3β or mPTP.
Subsequent experiments demonstrated that manipulation of epigenetic mechanisms could reverse these gene expression alterations, as well as the related behavioural phenotypes in adult offspring 23.
Therapeutic manipulation of the mechanisms involved in recruiting myofibroblasts from these different sources may therefore hold potential for modulating cardiac remodelling under different pathological conditions.
With no current treatment available for AC, it is highly attractive to consider that manipulation of molecular mechanisms underlying the development of the cardiac fibrofatty infiltration could mitigate both functional deterioration as well as survival of AC patients.
Epigenetic machinery is involved in the establishment of this pattern, and manipulation of its mechanism results in distinct patterns of var gene expression.
The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation.
The manipulation of co-stimulatory mechanisms by local gene therapy gave less conclusive results.
