Sentence examples for manipulation of histone from inspiring English sources

Manipulation of histone acetylation changes transcriptional cycle timing (Harper et al., 2011; Suter et al., 2011).

However, secondary metabolism gene clusters can be directly activated by manipulation of histone methylation [ 24] or histone deacetylation related genes [ 25] as well as induction of a cluster's Zn2Cys6 transcription factor [ 26].

The pharmacological manipulations of histone deacetylase activity have been beneficial in various experimental models of central nervous system disease such as Huntington's disease, epilepsy, and Alzheimer's disease.

Through the use of histone deacetylase inhibitors and manipulation of the Rpd3 gene dosage, we have also shown that histone deacetylase contributes to Gro activity in an intact tissue, namely the Drosophila wing disc.

We then postulated that global manipulations of the histone code using chromatin modifying agents could change the cell-specific chromatin conformation of fibroblasts and render it more prone to activation by transfected oligodendrocyte-specific TFs.

Our findings describing the first directed manipulation of a specific histone modification within a defined centromere strongly support the hypothesis that H3K4me2 is an essential part of the chromatin environment of vertebrate kinetochores required for long-term kinetochore maintenance and function.

For example, in cultured cells pharmacological manipulation of the acetylation status of histone 4 influences rRNA expression [31], [39].

In this study we asked whether combining global manipulation of DNA methylation and histone acetylation together with the expression of oligodendrocyte- specific TFs, was sufficient to switch the identity of fibroblasts into myelin gene-expressing cells.

In this model, the adult nervous system is supplied with wildtype levels of CBP during development, but as levels drop during our experimental manipulations of aging adults, histone modifications required for more open chromatin configurations are slowly eroded.

Tropberger, P. et al. Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation.

Therefore, manipulation of gene expression is possible by tuning specific histone methylation marks positioned within H3 and/or H4 histone proteins.