We want to understand cause and effect in the science of organizational design through experimental manipulation of factors.
Because some of these proteins are enriched at the neuromuscular synapse, the manipulation of factors governing synaptic transcription is a promising new approach to the treatment of muscular dystrophy.
This would allow for the effective manipulation of factors involved in the UPR, which could prove extremely valuable in developing therapeutic treatments for such diseases.
Such gene therapy or stem cell engraftment approaches may enable the localized manipulation of factors to induce remyelination within various types of MS lesions.
Optimization of HAC formation may theoretically be achieved by the systematic identification and manipulation of factors that affect the efficiency of formation and subsequent stability of each of these key functional elements.
Further, Hoagwood and Kolko (2009) suggest that a more thorough understanding of the community services context would allow for the identification and potential manipulation of factors that mediate or moderate implementation, thus improving the overall applicability of EBPs to community care.
