Sentence examples for manipulation of endogenous from inspiring English sources

Indeed, a growing number of studies are revealing that precise definition of the GRKs involved in receptor regulation can only be truly defined in a system endogenously expressing the receptor of interest and through manipulation of endogenous GRK populations.

Yi, J. J., Wang, H., Vilela, M., Danuser, G. & Hahn, K. M. Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides.

However, it is unknown whether manipulation of endogenous leptin secretion alters ingestive behavior in otherwise healthy subjects.

These results indicate that CP accumulation in tomato is tightly controlled by the jasmonate signaling pathway, and provide proof-of-concept that the production of some plant secondary metabolites can be enhanced by transgenic manipulation of endogenous JA levels.

This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A1 and A2 receptor antagonist, on its actions.

The results of this study indicate that chronic administration of amitriptyline is effective in alleviating thermal hyperalgesia, but not static tactile allodynia, in the hindpaw ipsilateral to nerve injury, and the block of this effect by caffeine suggests that this effect is partially achieved through manipulation of endogenous adenosine systems.

Discriminating between these possibilities becomes particularly important for studies aimed at compensating the age-related decline in neurogenesis though manipulations of endogenous NSCs either by controlling their cell cycle entry versus exit or, alternatively, by manipulating their cell fate change versus survival.

Furthermore, we have combined confocal imaging with biochemical and molecular biological manipulation of individual GRK and arrestin subtypes to identify their roles in the regulation of endogenous P2Y-receptor-stimulated PLcontractiong and coftraction of MSMCs.

59 However, all the previous techniques have some limitations, such as gene size, overexpression, or cell type specificity, which can be solved with a direct manipulation of the endogenous mutated gene, either by repairing DNA mutations or manipulating the splicing mechanism.

All of these approaches involve non-pharmacological manipulation of the endogenous control systems of the animals and complement the detailed information from ultrasound that is now becoming available.

Manipulation of the endogenous cannabinoid (eCB) system has become a major focus of current research, especially in the search for novel therapeutics to treat many common mental illnesses, including anxiety disorders, depression, and drug addiction (Porter and Felder, 2001; Kathuria et al, 2003).