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More sophisticated manipulation of effector cell populations including antigen-presenting cells, T cells, and B cells remains a possibility, but will be limited to some extent by the re-emergence of pathogenic clones.
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Second, verification through the manipulation of auxin effectors is also not foolproof, as there is evidence that the downstream factors influence transport and hence the distribution of the upstream gradient that controls their expression [ 56].
Manipulation of the increased number of effector cells, such as NK cells and monocytes expressing Fcγ receptor, which binds to the Fc of rituximab, might be useful for patients with B-cell non-Hodgkin's lymphoma cells regarding the efficacy of rituximab.
With further understanding of TLR function, signalling and effector mechanisms, manipulation of this pathway holds great potential in cancer treatment.
Type 3 secretion systems (T3SS) have been thoroughly studied for their role in transport of effectors allowing the manipulation of eukaryotic cells by pathogenic E. coli.
Boyden chamber assays were used to measure cell migration in response to manipulation of Brk and downstream MET effectors.
Efficient host cell manipulation is based on the delivery of a complex mixture of effector proteins.
Immunotherapy is an emerging and now successful treatment modality for numerous cancers that relies on the manipulation of the immune system and its effector functions to eradicate tumour cells.
Our observations support the idea that galectin-1 may contribute to immune privilege of tumours by modulating survival or polarisation of effector T cells, and suggest a potential molecular target for manipulation of T-cell apoptosis with potential implications in immunotherapy.
The maximum displacement of the manipulation end-effector is calculated and an error analysis is conducted.
A more comprehensive knowledge in the molecular mechanisms that regulate ILC development and effector functions may allow for therapeutic manipulation of ILCs for diverse disease conditions.
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