Sentence examples for manipulation of donor from inspiring English sources

The genetic manipulation of donor lymphocytes with a suicide gene is a promising strategy to increase feasibility and safety of allo-HCT.

Previous attempts to investigate HSC proliferation history have been limited to assays that involve in vitro manipulation of donor cell populations for efficient labeling, or that require fixation to permit experimental readout [2], [3], [5], [8], [22].

First, it implies that spiral ganglion-derived SPCs are ready to adopt a spiral ganglion cell fate without the need for further genomic manipulation of donor cells.

During this procedure, manipulation of the donor endothelium Descemet membrane layer within the recipient anterior chamber can be associated with loss of the correct anterior-posterior orientation.

This method allows the genetic manipulation of the donor somatic cells prior to transfer into an enucleated oocyte.

Genetic manipulation of the donor chondrocytes accelerated early healing, but ultimately there was little difference from controls.

An alternative approach to patient-specific autologous cell replacement that would also not require genetic manipulation of the donor cell population prior to delivery would be the use of either genetically unmatched ES or tissue-specific precursor cells.

Another attractive possibility is further genetic manipulation of the donor pig to suppress the T cell mediated response, for example by the transgenic, graft-mediated local expression of immunosuppressive agents such as CTLA4-Ig 38 or anti-CD2 mAb 39.

However, despite these successes, the reality of using cellular carriers for tolerance induction in the clinical arena is associated with the considerable cost and complexity of ex vivo laboratory manipulation and the high number of donor cells required.

A SmaI restriction site was designed to replace an array of 13 nucleotides in the first coding exon of chameau in the donor plasmid, manipulation of which leads to a frame shift after the homologous arms (HA-L, 1.0 kb, and HA-R, 2.2 kb) are recombined with the endogenous DNA segments (Fig. 1B; supplementary material Table S3; Fig. S2).

Moreover, the fragmentation of parties and the strictness of party financing regulations regularly lead to long investigations into fund-raising, hiring and manipulation of the system to benefit donors or friends.