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In a second analysis, the manipulation of difficulty was maximised by selecting 60/100 trials with accurate responses which generated the fastest and slowest decisions for each participant.
Consistent with our predictions, the manipulation of difficulty for the semantic judgements produced activation in a distributed network associated with executive control of semantic decisions.
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Manipulations of difficulty and the speed accuracy trade-off illustrated that some parameters might be independent of stimulus modality (i.e., boundary separation), whereas others are not (i.e., drift rate and nondecision time).
These results suggest that perinatal administration of PCP may produce long-term alterations in cognition that are revealed by pharmacological challenge and manipulation of task difficulty.
Participants also underwent a purely behavioral Go/Nogo task, which included a manipulation of inhibition difficulty (blocks with 50 vs. 80% go-trials) and a Change-signal task that required switching to an alternative response.
Furthermore, an overall increase in activation within both hemispheres under higher task demands was evident only in the visual areas and area IPTO, indicating a successful manipulation of task difficulty on a neural level [29].
Manipulation of task difficulty has previously provided a strong contrast for the DLPFC and other regions of MD cortex in neuroimaging experiments (Duncan and Owen 2000; Woolgar et al. 2011).
However, unlike A. balhimycina, A. orientalis is not amenable for genetic manipulations because of difficulties encountered in DNA transformation [ 17].
A further question motivating this study was to what extent are there individual differences in the rostro-caudal spread of activation for different manipulations of task difficulty?
Perhaps surprisingly, even a simple manipulation of stimulus discrimination difficulty, with little need for complex cognitive control, has been shown to activate quite anterior regions of the PFC (Jiang and Kanwisher 2003a).
Replicating past studies, skilled readers, as indexed either by Nelson-Denny tests or Gernsbacher (1990) structure-building tests, showed no disruption in recall by either difficulty manipulation; indeed their recall was enhanced for certain combinations of difficulty manipulation and text type.
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