Sentence examples for manipulation of chromatin from inspiring English sources

Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem cell function.

The manipulation of chromatin organization is at the heart of a plethora of biological processes.

The controlled manipulation of chromatin structure offers an effective means of regulating these processes.

Use of chromatin-modifying agents showed that direct manipulation of chromatin dynamics had a marked effect on the extent of stochastic gene expression.

The manipulation of chromatin via the addition of functional groups to histone tails is referred to as chromatin modification, which serves two main purposes.

Epigenetic research has long been hindered by the lack of experimental methods that would allow the targeted manipulation of chromatin marks in living cells, since mutational approaches and pharmacological inhibition alter marks globally and nonspecifically.

Thus, a complex biological state of chromatin in vivo exercised an impact on physical manipulations of chromatin in vitro.

Collectively, these studies show that manipulation of single chromatin marks at relevant sites can significantly alter levels of transcription and that this effect depends on both the enzymatic activity of the chromatin modifier and its binding to the target site.

The histone code hypothesis postulates that modifications to histone tail residues may act in concert to create "on/off" switches that alter transcriptional tone through physical manipulation of the chromatin structure [ 29].

As such, our study identifies novel roles of Chd1 in terms of transcription related chromatin changes and places Chd1 as vital in the manipulation of metazoan specific chromatin structure.

Models for the experimental manipulation of large-scale chromatin structure in vivo and in vitro will be instrumental to determine the key cellular pathways and oocyte-derived factors involved in genome-wide chromatin modifications.