Sentence examples for manipulation of cholesterol from inspiring English sources
Thus manipulation of cholesterol can disrupt several T cell functions, which makes it difficult to draw conclusions and the functional role of plasma membrane condensation in T cell activation responses remains a fundamentally important, yet unanswered question.
For manipulation of cholesterol, medium was replaced with serum free medium 1 h prior to experimentation.
The manipulation of cholesterol content might thus have an immunomodulating effect.
Lipid raft perturbation e.g. by direct manipulation of cholesterol levels or by inhibition of glycosphingolipid synthesis impaired invadopodia formation and function [ 231, 232].
With statin treatment in place, no incremental manipulation of cholesterol, low density lipoprotein, or high density lipoprotein levels with a non-statin agent has been found to prevent events so far.
Some previous studies in endothelial cells had shown ATP responses to be modified by experimental manipulation of cholesterol [23,24], but others reported that treatment with MCD failed to alter the ATP-mediated Ca2+ response [25] and this seems to be the case in our dyslipidaemic animal model.
Thus we tested whether manipulation of cellular cholesterol levels that control SREBPs activation [20] could alter the expression level of Pdro.
Because of these characteristics, their use for the manipulation of cellular cholesterol content has been pervasive [2], although the precise mechanism of their actions has not been fully elucidated.
10.7554/eLife.08009.011 Figure 5. Manipulation of membrane cholesterol content affects inflammatory responses.
Thus, although cholesterol depletion may have other effects, we conclude that the appropriateness of MCD for investigating the effects of cholesterol manipulation and caveolae disruption has been demonstrated.
We have therefore used confocal microscopy to determine the effects of cholesterol manipulation in single myocytes but from intact coronary artery preparations.
