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In future, drugs like these or derivatives thereof may be used for the therapeutic manipulation of alternative splicing.
The manipulation of alternative PCD pathways may represent an attractive approach to increase the overall tumor cell-killing efficiency of glioma therapies.
Given the striking changes in the levels of STAT3α and STAT3β noted during myeloid differentiation [ 12– 14], and the interest in the directed expression of STAT3β in the place of STAT3α by manipulation of alternative splice regulation, further exploration of these mechanisms of these differences and transcription factor cross-regulation is clearly warranted.
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Mr. Ireland added that he was not aware of the investigation into manipulation of Next Alternative's shares.
Manipulation of the alternative pathway gene D-galacturonic acid reductase by over-expression in strawberry fruit resulted in a two- to three-fold increase in the total ascorbate content [ 20].
The decoy effect occurs when preferences between two alternatives reverse as a result of the manipulation of a third alternative (i.e., a decoy) such that it is dominated by only one of the two original alternatives.
In addition to the circular posts used by Nagrath et al., microposts on silicon chips have been designed to optimize capture through the manipulation of streamlines using alternative post geometries.
In the genomic era, the availability of the complete nucleotide sequence of the genome of different organisms has made possible the prediction of certain recurrent rearrangements, which in turn has resulted in a novel type of genetic manipulation leading to the construction of alternative genomic architectures.
We hypothesized that in the clustered condition, the average similarity between alternatives would decrease with N. The manipulation of the average angular distance between alternatives led to two clear hypotheses: The effect of the number of alternatives on MRT would be sublinear in the clustered condition, in line with Hick's law.
Furthermore, the manipulation of vitamin level provided an alternative tool to realize metabolic engineering goals.
The effect of ChABC that we have demonstrated suggests that manipulation of PNNs might be an alternative way of restoring memory, at least temporarily, in neurodegenerative disease.
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