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We argue that this design may underestimate the effect of the manipulation due to carry-over effects.
It is often open to strategic manipulation, due to dependence on irrelevant alternatives, and it tends to impose particular and unjustified non-linearity in bid prices.
The case series included two patients with PES and one patient with LE secondary to extensive airway manipulation due to an unanticipated difficult airway of unknown cause.
Health economic evaluations in general are vulnerable to manipulation due to the use of primary data and the arbitrary definition of outcomes.
Furthermore, the animals were under full anaesthesia and not exposed to any additional manipulation due to the inclusion in this study.
Examining pain reported in the absence of manipulation due to dressing change or after wound healing may be indicative of a chronic pain condition.
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Limitations of the present study include a small sample size with results for just one manipulation only, due to ethical issues of receiving multiple manipulations.
This is a critical feature for cancer patients as many of them are undergoing chemotherapy that can make typing or finger manipulation difficult due to neuropathy in their fingers.
In this study, we find that climatic changes both directly and indirectly alter seedling emergence and establishment and that changes in soil moisture, either directly from our manipulation or due to other climatic change factors, often had the most influence on seedling emergence and establishment across species, though treatment effects differed among species.
Both aberrant silencing and activation of target genes via Polycomb activity manipulation occur due to SYT-SSX.
In adults, there is no role for prophylactic antibiotics unless utilised for wound excision or manipulation procedures due to the risks of adverse events and anti-microbial resistance.
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