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Namely, it would enable both the particle manipulation and imaging using their magnetic properties and simultaneous stimulation of electro-sensitive cell types using their magnetic properties, which can be used in tissue therapy, engineering and as biosensors.
The large animal VX2 rabbit tumor model allows catheterization [1] using human catheters, vascular manipulation, and imaging using clinical machines and thus can be used to study the effect of pharmacologic vascular manipulation like AII on gene expression.
In the future it will be necessary to generate mouse models that more accurately recapitulate human breast carcino-genesis, while offering the advantages of model systems, such as easy genetic or pharmacological manipulation and imaging.
The diffracted and initial laser beam were used for cell manipulation and multiphoton microscopy, respectively (see manipulation and imaging beam in Fig. 1).
The robotic technique prevented the need of moving the patient in and out of the scanner bore for manipulation and imaging of the needle-guide.
However, recent advances in the state-of-the-art techniques, including single-molecule manipulation and imaging, have enabled an investigation of non-channel type cell mechanosensors and the underlying biophysical mechanisms of their activation.
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From clever behavioral assays, to sophisticated genetic manipulations and imaging of brain activity, the work describes how an important sensory cue is handled in different ways depending on the internal state of the animal (that is, hungry or not).
Zebrafish is also amenable to genetic manipulations and to imaging techniques for studying neural development.
Many experiments require the combined use of genetic manipulation, imaging, and electrophysiological recording, which make it desirable to use an in vitro preparation.
We sought to establish a system that is suitable to genetic manipulation, recording, imaging, and short-term pharmacological studies.
Shipley, F.B., Clark, C.M., Alkema, M.J. & Leifer, A.M. Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans.
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