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Yields were varied mainly by manipulating the duration and temperature of the aqueous washes prior to coupling, which affected the concentration of active sites available for subsequent GAG binding.
We attempted to control overall condition difficulty, keeping mean T1 performance at approximately 85%, by manipulating the duration of both targets in the following way.
Following Martens et al. [7], we attempted to control task difficulty, keeping mean T1 performance at approximately 85%, by manipulating the duration of the targets in the following way.
Except for visual targets, the duration of all stimuli was 120 ms. Following Martens et al. [12], we attempted to control task difficulty, keeping mean visual T1 performance equivalent to mean auditory T1 performance, by manipulating the duration of visual targets in the following way.
One aspect of the logic of these experiments is simple and serves to illustrate the main ideas: manipulating the duration of a processing stage prior to the bottleneck should not affect response time (it does not help much to speed-up and arrive fast if there is a cue at the end of the path).
Indeed, it was more recently shown that manipulating the duration of the G1 phase in neocortical apical progenitors alters the production of IPs and neurons (Lange et al., 2009, Pilaz et al., 2009).
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So the transportation department came up with a simpler -- and more economical -- tool to manage congestion: manipulate the duration of the traffic lights at cross streets, allowing more cars to move through the main road.
We manipulated the duration of the fixation dot, which was switched off 0.2, 0.5, 1 or 4 s after the onset of the motion stimulus.
The short spoken member of the pair (sika "pig") was recorded and manipulated: the duration of the first syllable was set to either 110 (short) or 135 (long) milliseconds with either a level (high) or a linear falling (fall) tone.
In particular, the data highlight the importance of methods that provide an ongoing measure of the activity of key components of the signalling pathway and methods that manipulate the duration of activity of these components.
Here, we used a color location Simon task (Simon & Rudell, 1967), in which we manipulated the duration of a pretarget fixation cross so as to predict with 80%% validity the congruency of the upcoming trial, analogous to the Wendt and Kiesel paradigm.
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