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Pathway models can be constructed manually by biologists and manipulated to study the dynamics of alternative pathways.
We took advantage of the purity and stability of these cells in culture, which can be genetically manipulated to study the role of Cx43 on GSC biology.
These graphs show how the tuning of different parameters (in the diffusion rates) can be synthetically manipulated to study different behaviors of the systems.
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From the perspective of tumor biology, the capacity to manipulate bacteria to study such processes – particularly the ability to rapidly modify and assess genetic mechanisms – may exceed the analogous capacity in mammalian tumor cells.
Furthermore, the use of plasmid vectors opens the possibility of genetically manipulating progenitors to study the impact of single genes on the clonal development of targeted populations.
The length of phase 1 was for the study manipulated to vary, in order to create a multiple baseline design.
However, the cell lines used in these studies were genetically manipulated to inactivate cell cycle checkpoints and to block apoptosis.
In the third study, task difficulty was manipulated to produce different error rates without altering certainty.
For example, the famous Facebook experiment [10] which manipulated users feeds to study emotional contagion, used LIWC [7].
Our results also demonstrate the feasibility of using recording from postnatally born neurons genetically manipulated by electroporation to study their functional properties.
Here, we manipulated time constants to study a whole range of integration dynamics, from near coincident (synchronous) spiking (∼1 5 ms) to rate fluctuations (∼50 500 ms) and even mean firing rate (>1 s).
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