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By utilizing an inducible cell clone we eliminated cell-related variations and manipulated the induction of p16INK4a and melanoma-associated p16INK4a variants, to obtain near-physiological expression levels.
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In this approach, the sensor measures the flux across the MR-fluid while a PI controller directly manipulates the magnetic induction level.
"The people around Bush manipulated the intelligence".
"He also manipulated the truth.
"They manipulated the markets".
SHC manipulated the materials.
Understanding this cellular dialogue may reveal how to manipulate the immune system to extend the stable phase and inhibit the induction of the rapidly accelerating disease phase.
To assess the dose-dependence of MyoD and its engineered variants on myogenic gene induction, we measured marker expression at various doses of MyoD by manipulating the concentration of doxycycline.
Finally, we manipulated channel activity in vivo and tested the effects of these manipulations on the induction of tinnitus.
Manipulating the expression of mutant or wild-type PIK3CA or DUSP1 confirmed that this mechanism is responsible for the induction of apoptosis and the inhibition of tumour proliferation in vitro and in vivo, to sensitise cells to AKT target therapy.
Direct evidence confirming CMS induction by this ORF is lacking in M. guttatus, hindered by the limited capacity to manipulate the mitochondrial genome in intact organisms, although this has been done in some species (reviewed in Hanson and Bentolila 2004).
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