Sentence examples for manipulate splicing of from inspiring English sources

Another precise method to alter disease progression is to manipulate splicing of exons within a gene transcript using splice-switching AOs.

We target virally encoded, catalytically inactive CasRx to cis elements of pre-mRNA to manipulate alternative splicing, alleviating dysregulated tau isoform ratios in a neuronal model of frontotemporal dementia.

Finally, we discuss the current technologies that can be used to manipulate alternative splicing and serve as potential cancer treatment.

The finding sheds light on the biological role of splicing in lifespan and suggests that manipulating specific splicing factors in humans might help promote healthy aging.

The development of AOs for manipulating alternative splicing has led to studies that focused on the therapeutic potential of AO-based exon skipping therapy for DMD.

And that you manipulate instead of mobilise.

In 1955, he composed musique concrète staple "Dripsody," which used tape loops and splicing to manipulate and contort the sound of a single drop of water.

To show that the role of hnRNPH and the changes in MADD and RON can be causative with respect to survival and invasiveness, we designed experiments to selectively manipulate the endogenous splicing events.

In these various experiments the Tcf7l2 gene is manipulated in different ways and each may alter the tissue specific splicing of the gene and in the case of the cDNA overexpression experiment only 1 isoform is represented.

For instance, with the splicing of plants, maybe you want to focus on how to manipulate cucumbers to produce a particularly crisp fruit through splicing.

In this report we demonstrate that decoy oligonucleotides designed against specific splicing factors can bind the splicing factor, affect alternative splicing of known targets and have biological effects in line with inhibition of their splicing activity.