Sentence examples for manipulate selectively from inspiring English sources

Little is known about the functions of basal forebrain non-cholinergic neurons, particularly corticopetal GABAergic neurons, largely because of the absence of specific research tools to manipulate selectively this projection.

The critical question is whether it will be therapeutically useful to augment angiogenesis and whether it will be possible to manipulate selectively the positive and negative effects of mediators such as ET-1.

The issues that must be addressed in SSc therefore are whether it would be therapeutically useful to augment angiogenesis and whether it is possible to manipulate selectively the positive and negative effects of mediators such as VEGF.

Whereas in rheumatoid arthritis the process is well characterized, with inducers of angiogenesis outweighing inhibitors [ 7], in SSc there is evidence of both increased and decreased angiogenesis, and the real challenge will be how to manipulate selectively the positive and negative effects of mediators to realize any therapeutic advantage.

In these nerve-muscle co-cultures AChR clustering is triggered in response to innervation, and when nerve and muscle cells isolated from normal and mRNA-injected embryos are mixed together, nerve or muscle can be manipulated selectively with exogenous molecules (Methods).

On the contrary, an optical tweezer can manipulate objects selectively, but cannot manipulate many objects simultaneously [19, 20].

Moreover, our genetic methods allowed us to manipulate Pcdhgs selectively in SACs, without directly affecting other neuronal types to which they connect.

By combining the expression of these promoters, coupled to either GAL4 (to drive transcription of a reporter gene) or GAL80 (to inhibit GAL4 function), it is possible to define subsets of clock cells and to manipulate them selectively by expressing genes whose products alter the electrical properties of the neurons or the running of the clock.

In addition to releasing GABA, SACs also release acetylcholine, the only retinal neuron to do so (Hayden et al., 1980; Famiglietti, 1983), so we used a line that expresses Cre recombinase from the choline acetyltransferase locus to mark and manipulate them selectively (Chatcre; Rossi et al., 2011).

The site of polymerization is regiospecified and the type of linkage in the network structure is manipulated by selectively blocking the ortho, para, and meta positions in the aromatic rings of the monomer.

Conversely, if a substrate cycle significantly impacts the consumption or generation of a particular cofactor, then the enzymes of the cycle could be manipulated to selectively adjust the cofactor level while minimally perturbing other parts of metabolism.