Sentence examples for manipulate p53 expression from inspiring English sources

Knowing the significance of p53 expression, the next hurdle is whether we can manipulate p53 expression to obtain more favorably outcomes.

Therapeutic strategies designed to alter or manipulate CD36 expression or function in taste buds may have important implications in treating obesity and related diseases.

Thus, treatments that manipulate MUL1 expression or activity may have potential as therapeutics strategies.

We used the Gal4-UAS system (Brand and Perrimon, 1993) to drive two RNA interference (RNAi) transgenes to manipulate cisd2 expression.

Furthermore, using in vitro and in vivo models to manipulate Azin1 expression, we have produced evidence of the importance of polyamines for AVP transcriptional regulation.

Given that we can manipulate RSP5 expression and thereby reduce levels of OLE1, we wanted to examine the effect of RSP5 depletion on Hsf1 activity in response to heat shock.

Several in vitro models have been used to manipulate ATP13A2 expression and show variation in cellular responses to Mn2+; Yeast devoid of YPK9, an orthologue of human ATP13A2, showed an increased sensitivity to Mn2+, while overexpression conferred resistance (16).

This promoter variant is predicted to affect transcription factor binding and it may therefore highlight a regulatory site that could be exploited to manipulate GDF5 expression and alleviate the detrimental effect mediated by the T-allele of rs143383.

To further address the role of Lxn-Rps3 interaction in cellular response to radiation, it would be necessary to manipulate Rps3 expression and examine its effect on radiation response.

We analyzed the impact of MS4a4B on T cell proliferation by manipulating MS4a4B expression with MS4a4B-expressing and –silencing approaches.

We used intracellular ROS production and caspase 3 activity as quantitative assays to determine the functional significance of manipulating AdipoR1 expression.