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Here, we provide neurobiologists with a timely review of the mechanisms and implications of SCI-induced lymphocyte activation, including a discussion of different experimental strategies that have been designed to manipulate lymphocyte function for therapeutic gain.
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Special emphasis will be made on the challenges and potential opportunities in manipulating lymphocyte function with RNAi.
These studies and our present findings suggest that CD98 could be a potential pharmacological target to manipulate lymphocyte activation and IEC-lymphocyte interactions during intestinal inflammation.
During infection, Y. pseudotuberculosis directly manipulates lymphocyte signaling and activation by expressing different virulence factors (12).
CD4+ lymphocyte function with early human immunodeficiency virus infection.
Mittrucker, H.W. et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.
Fang, D. et al. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.
Mittrücker, H.W. et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.
A novel role for caveolin-1 in B lymphocyte function and the development of thymus-independent immune responses.
Boni, A. et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.
Koshy, S. et al. Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma.
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