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Hussain, M., Frentiu, F. D., Moreira, L. A., O'Neill, S. L. & Asgari, S. Wolbachia utilizes host microRNAs to manipulate host gene expression and facilitate colonization of the dengue vector Aedes aegypti.
Accumulating reports have indicated that virus can produce miRNAs to manipulate host gene expression and facilitate viral replication [ 8].
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Viewing the expression profiles of the genes in these clusters (Figure 3) the co-operative nature of the EBNA3s in manipulating host gene expression is evident.
By providing an array of survival signals and manipulating host gene regulation, EBV influences and overrides a variety of molecular control pathways that are crucial for normal B cell function.
This is frequently observed in host-pathogen interactions, where the pathogen manipulates host gene expression to evade the immune response.
In addition, the wMelPop strain of Wolbachia was shown to increase both locomotor activity and metabolic rate in Aedes aegypti [ 37], suggesting Wolbachia can manipulate host metabolism by inducing changes in expression levels of host metabolic genes.
Successful pathogens use effector molecules, encoded by Avr genes, not only to suppress host immunity but also to manipulate host cellular mechanisms for their own benefit, leading to effector-triggered susceptibility (ETS 28.
The group of T. hominis families showing the greatest expression divergence also includes the hexokinase gene family, whose paralogues in the microsporidian N. parisii have been suggested to manipulate host metabolism following secretion into the host cell [ 16].
Among the latter, viral IAP genes (ORF 42, ORF 87 and ORF 99) were identified, suggesting that OsHV-1 may actively manipulate host apoptosis in order to multiply itself.
In fact many pathogens manipulate host responses through direct and indirect interactions between pathogen and host proteins.
The results of this study provide evidence for how bacteria can target host proteins to manipulate host cell activities.
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