Sentence examples for manipulate expression of from inspiring English sources
Here, we used virus-mediated gene transfer to manipulate expression of orexin peptides in young and aged rats and examined behavioral and neurochemical correlates of food intake in these animals.
The ability to manipulate expression of the mouse PPCD1 phenotype in different strains may provide important insights into how genes interact to influence ocular disease in mammalian systems.
It has a fully sequenced genome, and many genetic tools are available, including transgenesis and target-selected mutagenesis, which can be used to manipulate expression of aging-related genes (reviewed in [11], [12], [13], [14]).
We used the MS4a4B-retroviral vector to manipulate expression of MS4a4B in primary T cells, which were subsequently labeled with PHK-26, a red fluorescent dye, and analyzed T cell proliferation upon CD3/CD28 stimulation by flow cytometry.
In order to manipulate expression of HcDPPIVA in its native organism, we overexpressed it in H. capsulatum strain G217Bura5-23 by placing the open reading frame under the control of the heterologous H2B promoter and CATB terminator sequences on a multicopy plasmid.
Here, they used an inducible GeneSwitch System to temporally manipulate expression of the DN Dmp53 transgene.
These results demonstrate that altering the size and timing of critical weight, by manipulating expression of FoxO and Usp, has definitive effects on final adult body size.
In this study, we manipulated expression of the Mcl-1 protein in HCC cells by RNA interference and analyzed its impact on apoptosis sensitivity of HCC cells in vitro.
To investigate the role of KLF17 in TGF- β/Smad-mediated signaling, we manipulated expression of KLF17 by RNA interference (RNAi) in cancer cell lines and tested TGF- β responsive SBE-containing luciferase reporter (SBE-Luc) activities.
Ultimately, by identifying specific genetic variants that confer different radiosensitive phenotypes, we can test the validity of our hypothesis by manipulating expression of these genes in a tissue-specific manner.
To study the possibility of an off-target effect of C3 siRNA in cancer cells, we used ovarian cancer cells with low C3 expression (HeyA8) to induce tumor in mice, and we further manipulated expression of C3 in induced tumors using C3 siRNA and compared the growth of tumors in these mice to those tumors induced by the same cell line in mice treated with scrambled control siRNA (n = 5 in each group).
