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For example, the full activation of c-Raf-1 and B-raf is manifested only when phosphatidic acid physically interacts with a polybasic amino acid segment in these kinases [28].
To uncover specific physiological functions of miRNAs and other regulatory mechanisms acting with miRNAs during development, we performed a genetic enhancer screen for developmental defects that manifested only when miRISC function and another regulatory mechanism were both compromised.
Taken together, these data suggest that the mutagenic effect of acrolein adducts is manifested only when the extent of DNA damage is substantial; they also suggest that the propensity of acrolein adducts to induce mutations may be dependent upon variations in biological context, including specifics of a particular cellular genetic background and patterns of gene expression.
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It has always been an uneasy one, the inherent tensions manifest only when an accident on the road occurs and the foreigner is assumed to be in the wrong.
Across three studies we demonstrate that pictorial-based homophone priming effects manifest only when consumers subvocalize (inner voice) the homophone in the image.
It manifests only when he is reintegrating into society," Kozinchuk said.
Moreover, exposure to low O3 concentrations may cause subclinical effects that manifest only when triggered by a stressor, suggesting that the adverse health effects of ambient levels of air pollutants may be insidious and potentially underestimated.
These findings indicate that exposure to low O3 concentrations may cause subclinical/insidious effects that manifest only when triggered by a stressor, suggesting that the health effects of ambient levels of air pollutants may be insidious and potentially underestimated.
We speculate that the NCF dysfunction manifests only when insufficient afferent drive is present to fully trigger the descending modulatory system.
While forebrain-specific knockout mice display a depression-like phenotype in adulthood under basal conditions, heterozygous GR mice possess a heightened vulnerability that manifests only when animals are exposed to challenging situations through a specific external stressor such as restraint- or footshock stress [16], [17], [18].
Patients usually present with slow-growing painless masses that manifest only when the tumours become huge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com