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It is most prominently manifested in mice deficient in the BMAL1 protein.
Whether the degree of cryptococcal strain virulence manifested in mice is comparable to the human host remains unknown.
This shows the role of the extracts and fractions in preventing radical anemic conditions that were manifested in mice in negative control due to severe infection.
As findings of the acute toxicity test indicate, no gross behavioral changes such as impaired movement, reduced motor activity and mortality were manifested in mice that were treated with single dose of 2000 mg/kg.
On the other hand, lower platelet count, a condition known as thrombocytopenia, was manifested in mice chronically exposed to khat prior to the infection irrespective of dose of khat extract.
Hence, the autoimmune disorder that previously manifested in mice lacking Bim appears to depend upon genetic background, even when Bad is also absent, and genetic background may well also have contributed to the low-penetrance lymphoid malignancy reported for aged Bad-deficient mice. 10 The Bcl-2 family governs the circulating life-span of platelets.
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Neurodegenerative diseases, particularly PD, are often associated with bradykinesia (Lees et al., 2009), a symptom manifested in mouse models of DA neuronal loss (Li et al., 2009).
These include mitochondrial myopathy and cardiomyopathy due to complete, or almost complete, loss of translocase function (Palmieri et al., 2005), which also manifests in mice in which Ant1 has been knocked out (Graham et al., 1997; Narula et al., 2011).
The genes within the genetic regions designated Aec1 (Idd5 on chromosome 1) and Aec2 (Idd3 on chromosome 3) appear sufficient for the manifestation of a SS-like disease phenotype comparable with the one manifested in NOD mice [ 41].
Interestingly, kallikrein-13 has recently been suggested to play a role in the etiology of the SS-like disease manifested in IQI/Jic mice [ 39].
Lastly, Toll-like receptor 3 engagement through polyinosinic:polycytidylic acid has been studied in an attempt to recapitulate the effect of a dsRNA virus infection on the SS-like disease manifested in these mice [ 24].
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