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Chronic alcohol intake leads to the development of alcoholic cardiomyopathy manifested by cardiac hypertrophy and contractile dysfunction.
Myocardial geometry and function were compromised with fat diet intake as manifested by cardiac hypertrophy, enlarged left ventricular end systolic and diastolic diameters, fractional shortening, cardiomyocyte contractile capacity and intracellular Ca2 + mishandling, the effects of which were ameliorated by catalase.
Among a wide array of comorbidities associated with obesity including type 2 diabetes, hypertension, cancer and sleep apnea [1], heart disease, which is mainly manifested by cardiac hypertrophy and compromised ventricular function, may lead to heart failure or premature death [7] [9].
AKAP9 mutations cause long-QT syndrome manifested by cardiac arrhythmia [ 18, 19].
The myopathic state of the heart due to alcohol consumption, namely alcoholic cardiomyopathy, is manifested by cardiac hypertrophy, compromised ventricular contractility and cardiac output.
In skeletal muscle AKAP9 is predominantly localized subjacent to acetylcholine receptors in the neuromuscular junction and was seen within the Z-line [ 16], and in cardiac muscle it has been recently identified as a gene associated with long-QT syndrome (LQTS), manifested by cardiac arrhythmia [ 18].
Similar(54)
Blood ejected into a rigid aorta encounters increased flow resistance that is manifested by increased cardiac work and elevated systolic blood pressure.
Further, antagomir-mediated knockdown of miR-499 aggravated cardiac remodeling as manifested by hypertrophy and impaired cardiac functions.
Sustained hyperglycemia with insulin resistance in the high fat fed moderate dose STZ rat is associated with cardiac sympathetic dysregulation manifested by elevated plasma and cardiac NE, reduced NET expression, and depleted [C]HED retention with maintained sympathetic nerve density.
At that time, cardiac disease, as manifested by reduced fractional shortening (Figure 6B), cardiac hypertrophy (Figure 6C), intracellular aggregates (Figure 6D and E), amyloid oligomers (Figure 6D and F) and interstitial fibrosis (Figure 6G) were observed (Figure 6B G).
Cardiac tamponade is manifested by flattening and a reduction of the cardiac parts (Fig. 26) [70].
Related(19)
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