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Selectins mediate the initial, low-affinity leukocyte-endothelial cell interaction that is manifested as leukocyte rolling.
Upregulation of complementary adhesion molecules and ligands on leukocytes and endothelial cells induced by bacterial products and proinflammatory mediators initiates a multistep process that includes initial contact between leukocyte and endothelium, followed by a weak transient adhesive interaction, manifested as leukocyte rolling, followed by firm leukocyte adhesion to the vessel wall [ 20].
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A major and serious pathologic change of scrub typhus is a focal or disseminated vasculitis due to the destruction of endothelial cell lining of the small vessels, which is manifested as perivascular infiltration of leukocytes [ 17- 19], an increased vascular permeability with extravascular protein loss, and consequently the hypoalbuminemia.
The host response to the vascular injury was manifested as intramural and perivascular infiltration by polymorphonuclear leukocytes, small lymphocytes, and macrophages.
This CAM-regulated process of leukocyte recruitment often results in endothelial cell dysfunction, which can be manifested as either impaired endothelium-dependent vasorelaxation in arterioles, excess fluid filtration in capillaries, and enhanced protein extravasation in venules.
And so it goes, restless change manifested as immortality.
This is manifested as an indeterminism of the theory.
Cardiac involvement is most frequently manifested as left ventricular hypertrophy.
6.6% of MM manifested as intramuscular calcifications.
This increased activity is manifested as greater functional connectivity.
Alveolar echinococcosis primarily manifested as a liver disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com