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Since the ciliary defects in some zebrafish and medaka PKD models are manifested as impaired urine flow rate [13], we performed dye excretion experiments to determine whether pronephric urine flow was normal in pc mutants.
The resulting outcome was a failure of differentiation manifested as impaired lactation.
This association raises the possibility that sepsis stimulates RAS, which contributes to microvascular perfusion heterogeneity (manifested as impaired response to local ischemia), and that perfusion heterogeneity contributes to organ failure.
Endothelial dysfunction may contribute to increased systemic vascular resistance and thus lead to the development of hypertension and is commonly manifested as impaired endothelium-dependent vasodilation due to an imbalance between vasoconstrictors and vasodilators [ 64].
Fatigue sensation is not fatigue itself, since fatigue sensation is involved in the biological alarm to order rest under the condition of fatigue; while fatigue itself is involved in the neural damage manifested as impaired performance [ 2].
Although clinical symptoms of autonomic dysfunction usually occur late in the course of diabetes, subclinical CAN, manifested as impaired HRV, may be detected within 1 year of diagnosis in type 2 diabetes and within 2 years of diagnosis in type 1 diabetes (15).
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These impairments manifest as impaired cognitive control of mood, pessimism, reactive aggressive traits, impaired problem solving, over-reactivity to negative social signs, excessive emotional pain, and suicidal ideation, leading to suicidal behaviour.
Liberal MP Sharman Stone, who chaired the committee, told Guardian Australia a lack of formal recognition of the condition meant that children with FASD, which manifests as impaired brain development, were either misdiagnosed and treated as being on the autism spectrum, or not treated at all.
Hematopoietic defects manifest as impaired lymphopoiesis in the marrow (Fig. 2), coupled with increased myelopoiesis (Fig. 5).
This has important functional consequences, manifesting as impaired calcium transport by sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) and loss of excitation-contraction coupling [ 21, 41].
This CAM-regulated process of leukocyte recruitment often results in endothelial cell dysfunction, which can be manifested as either impaired endothelium-dependent vasorelaxation in arterioles, excess fluid filtration in capillaries, and enhanced protein extravasation in venules.
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