Our results support the role of π-π interaction, which is consistent with single channel analysis of the inhibition by local anesthetics; two distinct types of inhibition were observed at single channel level: rapid block (manifested as decreased single-channel conductance), and discrete block (appearance of distinct closed periods).
Our findings of pain desensitization, manifested as decreased subjective pain threshold pre- to post-self-treatment on the treated leg, corroborate these findings in the literature.
The decreased functional connectivity between motor cortex and PAG was also demonstrated in fibromyalgia patients [26], which was also demonstrated in this study and it suggested that vlPAG dysfunction manifested as decreased contralateral functional output from premotor and SMA, and the neuromechanism should further be elucidated.
Patients with AIDS have an abnormality of retina/optic nerve function, manifested as decreased contrast sensitivity (in the absence of ocular opportunistic infections or media opacity), abnormalities on automated perimetry, and loss of retinal nerve fiber layer, even among those with good visual acuity, termed the "human immunodeficiency virus (HIV) neuroretinal disorder".
The reduction in intratho-racic pressure manifested as decreased central venous pressure.
The dyslipidemia is typically manifested as decreased HDL cholesterol, increased LDL cholesterol (including small, dense LDL), and increased total cholesterol.
The dyslipidemia associated with cART administration is typically manifested as decreased HDL cholesterol (HDL-C), increased LDL-C (including small, dense LDL), and increased total cholesterol.
A possible mechanism for the decreased atherogenesis is the anti-inflammatory effect of metoprolol, manifested as decreased serum levels of proinflammatory cytokines TNF α and CXCL1 and, consequently, decreased macrophage content in the atherosclerotic plaques.
These results suggest that ER -and PgR-negative status and high LI cell kinetics may be useful markers for identification of patients who have a poorer clinical outcome manifested as decreased overall survival.
In addition, aged chondrocytes exhibit an impaired ability to respond to mechanical and inflammatory insults, manifested as decreased anabolic activity and an increase in catabolic activity, thereby compromising cartilage extracellular matrix integrity [ 4, 5].
