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The monitoring and genotyping of Enterovirus (EV) infections can help to associate particular or severe clinical manifestations with specific EV types and to identify the aetiology of infectious outbreaks.
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This surveillance provides valuable data on the epidemiologic pattern and clinical manifestations associated with specific genotypes and provides vital information that can be used to control annual EV epidemics.
In subsequent analyses, we will test whether the clinical manifestation corresponds with specific mechanisms (see below).
Leptospirosis has a wide range of clinical manifestations with non-specific signs and symptoms and often misdiagnosed with other acute febrile illnesses at early stage of infection.
We also analyzed the association between clinical manifestations and infections with specific Cryptosporidium spp. and C. hominis subtype families.
1) Although a relatively large number of patients with NP manifestations were included and we did detect a correlation between CNS disease and specific antibodies, we were unable to correlate specific antibodies with specific manifestations, since the study was not adequately powered for them.
Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US) are frequently used to assess end organ damage in patients with specific manifestations.
Our major novel finding is that individuals with specific manifestations of DSPN have higher serum IL-1RA levels that cannot be explained by anthropometric or metabolic confounders.
Rare variants of relatively large effect size may be enriched in patients of certain manifestations, such as patients with specific subphenotypes, early onset age, or familial aggregation.
However, neither serotype was significantly associated with specific clinical manifestations, which suggests that manifestation development among IGASI might be attributable to host or environmental factors rather than the pathogen.
Although the epitope specificity using linear peptides was not originally reported to be associated with specific clinical manifestations of the syndrome, more recently a close association between anti-domain (D)I reactivity and vascular events has been suggested [ 67].
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