Exposure in utero to alcohol can cause irreversible brain damage, with visible manifestations that include smaller eyes and a smaller upper lip with the lip's groove flattened.
coli), also referred to as Shiga toxin (Stx) -producing E. coli (STEC), infection is associated with a spectrum of clinical manifestations that include diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS) [1] [3].
Thus, twin and family data have demonstrated that the liability to autism also confers a risk for a broader range of manifestations that include other forms of pervasive developmental disorder (PDD), such as atypical autism, Asperger's syndrome and 'other' PDD, as well as subtler manifestations that extend beyond traditional diagnostic boundaries [3], [4].
19, 20 A minority of patients with MTC present systemic manifestations that include diarrhea, flushing, or painful bone metastases.
Dentatorubral-pallidoluysian atrophy (DRPLA) is an inherited autosomal dominant neurodegenerative disease with clinical manifestations that include dementia, ataxia, epilepsy, chorea, and psychological disturbances.
Dogs that represent an immediate risk for transmission of Leishmania in endemic areas present clinical manifestations that include onicogriphosis, skin lesions, conjunctivitis, lymphadenopathy, and weight loss.
The majority of patients had disease manifestations that included ANA positivity (97%), immunologic disorder (89%), arthritis (87%), hematologic disorder (64%), or malar rash (56%) at the time of diagnosis.
Smoking is associated with increased production of autoantibodies, including ACPA and rheumatoid factor (RF) and with increased incidence of extra-articular manifestations in RA that include the development of rheumatoid nodules [ 16, 17].
But before reaching such endstages, CVD goes through a range of manifestations that also include edema and skin changes (venous eczema, ankle skin hyperpigmentation, atrophie blanche, and lipodermatosclerosis).
Untreated Lyme disease may lead to late manifestations that can include chronic arthritis, neurological abnormalities, cardiac complications, and skin lesions.
Sjogren's syndrome (SS) is a common autoimmune disease characterized by dry eyes and dry mouth along with associated clinical manifestations that can include interstitial lung disease, kidney disease, neuropathy, vasculitis and lymphoma [ 1, 2].
