The hereditary and spontaneous AD models, such as murine (BXSB) lupus, are characterized by autoimmune manifestations that affect the majority of the animals of a susceptible line and by a strong genetic predisposition displayed by the HSCs and manifested by anomalies of thymic development and/or function of lymphocytes B or T or antigen-presenting cells such as macrophages.
Although cognitive impairment is the most relevant symptom, dementia is usually also associated to different behavioral, psychological and functional manifestations that affect the functional and executive capacities of the individual - interfering with normal family, social and occupational activities, and lessening the quality of life of both the patients and their caregivers.
Migraine is a common, disabling, primary headache disorder, with episodic manifestations that affects women three times more than men [1].
Interstitial lung disease (ILD) is the most common internal organ manifestation that affects the prognosis of clinically amyopathic dermatomyositis (CADM), as well as polymyositis (PM) and dermatomyositis (DM).
These consequences amongst others, that result from SCD has a broad manifestation that affects various organ systems in the body [ 6], of which chronic kidney disease (CKD) is a part.
We hypothesize that some subpopulations of the parasite may be associated with disease manifestations and with factors that affect the transmission dynamics of L. braziliensis strains, such as various sandfly vectors present in the study area (9, 10 ).
An organization of elders who have the ability to manipulate these forces meets at night to repair those manifestations of akombo (e.g., epidemics) that affect the group; these phenomena require human sacrifice or its metaphorical equivalent.
Under such mode of protein evolution, once an amino acid substitution is fixed, the probability of its reversal declines as the protein sequence accumulates changes that affect the phenotypic manifestation of the ancestral state.
We base these parameters on physiological manifestations caused by hypertension, as well as other comorbities that affect the geriatrics community.
Such altered genes can give rise to different clinical manifestations through gain-of-function (enhance) or loss-of-function (attenuate) mutations that affect the channel activity.
As mitochondria are present in all cells of the body, mitochondrial disorders have very complex manifestations that can affect diverse organs such as the heart, the endocrine system (causing, for example, diabetes), and, for reasons not always well understood, some but not other aspects of brain function.
