Fabry Disease is still hard to diagnose because of its features and because it has clinical manifestations overlapping to other pathologies and subsequently a wide range of differential diagnoses that involve several clinical specialties [ 18].
The non-specific clinical manifestations largely overlap with those of ABP, and include fever, dysuria or frequency, dull pelvic or perineal pain, rectal tenesmus, prostatic tenderness at digital rectal examination, and sometimes acute urinary retention.
The multifactorial aetiology, the similar clinical manifestations and overlapping of the multiple signs and symptoms of TMD makes its clinical management a complex task to overcome [ 1, 2].
Interestingly, hand foot skin reaction – regarded as a manifestation of overlapping toxicity of infusional 5-FU and Caelyx – was observed in only four patients treated at the recommended dose level (24%), although the investigators were vigilant to the possibility of this adverse event and no prophylactic measures (e.g. vitamin B6) were in place.
Clinical manifestations can overlap with another similar syndrome – thrombotic thrombocytopenic purpura (TTP).
Because the clinical manifestation of vCJD can overlap that of sporadic CJD, brain autopsies should be sought in all suspected cases to establish the diagnosis and to help monitor the occurrence of vCJD and other potentially emerging forms of CJD.
Fluorosis is a slow, progressive, crippling malady, which affects every organ, tissue and cell in the body and results in health complaints along overlapping manifestations with several other diseases.
As mentioned earlier, uveitis and arthritis have overlapping manifestations, and because the relation between TRAF5 with uveitis has not yet been reported, we decided to investigate the role of TRAF5 polymorphisms in two forms of uveitis, AAU and pediatric uveitis.
Although HUS patients are, typically, young children with a history of diarrhea and acute renal failure, the clinical manifestations of HUS and TTP often overlap, making differentiation between the two syndromes based solely on clinical presentation difficult.
Up to 84% of patients with IBS have a positive LBT, suggesting that the etiology and symptom manifestation of IBS and SIBO may overlap [ 4].
