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An overview of the neurological manifestations of thyroid dysfunction.
It follows that these antibodies might be more relevant to cardiac manifestations of thyroid disease.
Nevertheless, we acknowledge that 53 85% of oncology patients treated with sunitinib develop thyroid test abnormalities, and a substantial percentage develop clinical manifestations of thyroid dysfunction (Desai et al, 2006; Rini et al, 2007).
Nevertheless, only five of these positive cases showed minor, transitory thyroid function test alterations, compatible with hypothyroidism in four cases and with hyperthyroidism in one case, but none of these showed clinical manifestations of thyroid dysfunction.
However, none of the ANA-positive participants met the 1982 ACR criteria necessary for the diagnosis of SLE, none with increased anti-TPO antibodies showed clinical manifestations of thyroid dysfunction and none of the AMA-positive individuals had clinical manifestations of liver disease.
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Thyroid dermopathy is an uncommon manifestation of autoimmune thyroid disease.
Thyroid dermopathy is an infrequent manifestation of autoimmune thyroid disease characterized by localized thickening of the skin commonly seen in the pretibial area.
In this review, the neurological manifestations of genetic disorders of thyroid metabolism are outlined, with particular focus on Allan-Herndon-Dudley syndrome and benign hereditary chorea.
Autoimmune thyroiditis may be associated with the entire spectrum of function (overt hypothyroidism, subclinical hypothyroidism, thyrotoxicosis), but has recently been associated with neuropsychiatric manifestations even in the absence of thyroid hormone abnormalities (for a review see Leyhe and Müssig 2014).
One should enquire about a personal or family history of BHD manifestations in patients with a diagnosis of thyroid clear cell carcinoma, and refer them for germline FLCN analysis when appropriate.
Because hypothyroidism can aggravate some of the clinical manifestations of WBS and is a treatable condition, periodic monitoring of thyroid hormone levels in WBS patients is recommended.
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