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Disease onset may be insidious or abrupt, typically occurring around adolescence, and is characterized by excessive daytime sleepiness, cataplexy (sudden loss of muscle tone triggered by emotions) and other manifestations of abnormal Rapid Eye Movement (REM) sleep.
Given the extreme complexity and quickly changing nature of this behavioral phenotype in mice we elected to perform unbiased computerized assessment of abnormal movement behaviors in locomotor activity chambers, rather than just simply applying ethological scoring approaches developed for other manifestations of abnormal behavioral activation, such as stereotypies and dyskineisas.
Thus, at least some clinical features of UFS should be regarded manifestations of abnormal development.
People at risk of developing type 2 diabetes show reduced microvascular hyperaemia (20) and decreased brachial artery reactivity (21), manifestations of abnormal endothelial function with decreased vasodilation (22).
Most studies designed for assessing teratogenic effects focus on only three of four types of final manifestations of abnormal development; namely intrauterine death, malformations, and growth retardation.
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Nevertheless, this abnormal behavior is an overt manifestation of abnormal motor function linked to cell loss in Dlx-CKO and other symptomatic dystonia models (Liang et al., 2014).
Atg-deficient mammary glands from retired breeders exhibit ductal ectasia, which, although not considered a preneoplastic change, is a manifestation of abnormal mammary gland remodeling.
Similarly, Smith GC, et al. reported that prior cesarean section was associated with unexplained stillbirth in subsequent pregnancy and suggested that this association might be manifestation of abnormal uterine blood flow caused by intentional or inadvertent ligation of major uterine vessels during prior cesarean section and abnormal placentation caused by uterine scar [ 20].
These experimental clinical manifestations of the abnormal concentrations of this neurotransmitter in the body of humans were also corroborated by similar findings in human samples that were used to see the effects of this neurotransmitter on the performance of their nervous system.
An epileptic seizure is the manifestation of an abnormal and excessive synchronized discharge of cerebral neurons.
It has recently been recognized that cancer is a manifestation of both abnormal genetic and epigenetic events [ 1].
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