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There were no statistically significant differences between cases and controls for any of the 53 combinations of SNPs that we observed in either ethnic group (table 3 and fig. 2) We went on to investigated the role of TIRAP variants in relation to disease manifestations by comparing the frequency of each variant in patients with pulmonary compared to disseminated TB.
We have previously studied the penetrance of the HFE mutations with respect to haemochromatosis disease manifestations by comparing the predicted birth rate of HFE C282Y homozygotes in our study population of 500,000 with the incidence of HFE C282Y-homozygous patients diagnosed with haemochromatosis, cirrhosis [ 10], liver cancer [ 11], arthritis [ 12] or diabetes [ 13].
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The role of another variant, Pro115Gln polymorphisms, on the pathogenesis of obesity, type 2 diabetes, and related metabolic disorders was investigated in a Caucasian cohort, and no significant differences were found in lipoprotein metabolism and diabetes manifestation by comparing the different genotypes [ 16].
Relationship between genotypes and the phenotypes were studied by comparing disease manifestation in patients with different combination of mutations.
The manifestation of synergy/antagonism was determined by comparing the expected ORR as obtained from the null model ORR1 = 100%q122 with the ORR as observed ORR0 = 100%p122.
By comparing gene expression profiles before and after the manifestation of clinical disease, Yost et al. [ 2] were able to define functional signatures that distinguished the early metabolic activities occurring at progressing sites from those at non-progressing sites.
By comparing patients with various disease manifestations, Schotte et al. [ 22] found an association of the −174G allele with discoid skin lesions and anti-histone antibodies.
By comparing antibody concentrations in serum and cerebrospinal fluid, it is possible to detect intrathecal antibody production [ 18].-wrap-foot> Early manifestations can be observed after some days up to a few weeks after infection and are self-limiting.
By comparing cardioscopic images and biopsy findings, a cardioscopic diagnosis of myocarditis could therefore be established, and the interrelationships between histological changes, cardioscopic images, and clinical manifestations could be clarified more precisely.
Avoid price gouging by comparing four factors.
Prevalence of autoantibodies and clinical manifestation was compared by Fisher Exact test using Prism 5.0 for Macintosh (GraphPad Software, Inc., San Diego, CA).
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