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These human and animal disorders are recessive and their manifestations appear to result from a loss-of-function mechanism.
Prognosis for the disease is usually reserved, especially when ocular, cardiovascular, neurological, and gastrointestinal manifestations appear [6, 15, 16].
The specific age at which overt clinical manifestations appear is in close relationship to the individual repeat length [9].
Although clinical manifestations appear after the fifth decade, the atherosclerotic process begins early in life.
The carriers are apparently born normal; however, by 2-3 years old, clinical manifestations appear.
For example, about 30% HCC cases with normal serum AFP levels are hardly diagnosed before clinical manifestations appear.
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To establish the extent of the embryonic phenotypes that arise in lamin A-depleted zebrafish, we further studied the F1 generations of germline-positive zprogerin transgenic fish since their F0 parents showed normal reproduction up until severe aging-like manifestations appeared (Fig. 1D and E).
Respiratory manifestations appeared on a continuum.
Ocular manifestations appeared after liver transplantation, probably due to the intraocular production of mutant TTR [ 16].
The test was considered to be positive if at least one of these manifestations appeared: urticaria, laryngospasm, wheezing, abdominal pain, diarrhea or vomiting.
As in SLE, a combination of traditional and nontraditional risk factors, including inflammation and also extra-articular manifestations, appears to explain this increased risk [ 32- 34, 36- 41].
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