Additionally, the relationship between acute manifestations and the development of chronic manifestations of oxaliplatin-induced PN has not been fully elucidated.
Future research is warranted to determine whether there are biological mechanisms linking cutaneous manifestations of diabetes and development of skin cancers or whether the cutaneous manifestations of diabetes increase the probabilities of early clinical detections for skin cancers.
Our understanding of PD pathogenesis is rapidly evolving, boosted by a massive amount of research into the genetic causes of PD, the influence of genetic and environmental susceptibility factors on disease penetrance and manifestation, and the development of better models to test potential neuroprotective therapies.
This interest is both in its physical manifestations and in the development of a theory unifying and describing those manifestations in various systems such as laser beams, astrophysical objects, and brain neurons[1 ]
Important information to support future preventive strategies includes estimate of rates of disease, timing of disease initial manifestations; and for vaccine development, description of serotype distribution in different populations (5 ).
Thus, the SCID-hu mouse harbors a human microenvironment in the form of human fetal bone; the human BM milieu allows the expansion and development of measurable manifestations of MM in SCID mice, including bone lesions and angiogenesis.
Most patients harbored at least one autoantibody up to 9 years before the development of clinical manifestations and therefore diagnosis of SLE, in particular ANA and also antiphospholipid, anti-Ro and anti-La antibodies [32].
Another limitation of this study is the assessment of risk factors at baseline only, which makes it difficult to evaluate development of disease manifestations and other events during follow-up.
In fact, cross-employment represents a crucial form of organizational manifestation for the development and promotion of networks.
