Remarkably little progress has been made in the two decades since then, despite the F.M.L.A.'s manifest weaknesses.
Psychoanalysis has, and probably always will have, its manifest weaknesses, but it still stands as a distinguished secular blend of literature, philosophy and pedagogy that has the power to help people change their lives for the better.
Despite its manifest weaknesses, the government's appeal -- in a court that had a history of backing up cases relating to the "War on Terror" that were later overruled by the Supreme Court -- was successful.
Different is the case of patients who are seen when they start to manifest weakness, usually with onset in the pelvic girdle muscles.
In the fourth week, they manifested weakness and reduced movements.
Again, for each treatment, cells from FSHD1 subjects manifesting weakness had higher DUX4-fl levels than cells from their nonmanifesting relatives with the identical 4qA allele.
Again, Decitabine induced DUX4-fl expression in cells from FSHD1 individuals manifesting weakness in all four cohorts (15A, 28A, 29A, and 30A), while TSA alone had little to no effect.
Supporting this hypothesis, we found that myogenic cells from these FSHD1-nonmanifesting subjects have an intermediate epigenetic status at the pathogenic distal 4q35 D4Z4 repeat that is not as relaxed as that found in FSHD1 subjects manifesting weakness, but not as repressed as that found in healthy control subjects.
Here, we report a case of a 15-year-old male adolescent who initially manifested weakness in both lower limbs at the age when he learned to walk, and then gradually developed obvious gait abnormalities, muscle atrophy, and talipes equinovarus, accompanied with early-onset glaucoma.
We conclude that, with respect to the pathogenic distal D4Z4 repeat on the contracted 4qA allele (when appropriate), healthy subjects display DNA hypermethylation, FSHD1 subjects manifesting weakness display hypomethylation, and FSHD1-nonmanifesting subjects display intermediate levels of methylation, slightly but significantly higher than those of FSHD1-affected subjects.
In it and subsequent installments, Carter's manifest political weaknesses were duly noted, but he and his aides preferred to dwell on his strengths.
